Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided (...) novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Music Education in an Age of Virtuality and Post-Truth by Paul WoodfordPanagiotis A. KanellopoulosPaul Woodford, Music Education in an Age of Virtuality and Post-Truth (New York, Routledge, 2018)This book is provocative. And challenging. It is written with passion, aiming to induce controversy. And with good reason. For we live in times when populism professes an illusionary sense of community, invoking a seemingly 'anti-systemic' but highly hypocritical, racist, and (...) sexist discourse;1 in times where "bullshitting"2 has advanced to the highest governmental levels in many countries; in times where "authoritarian neoliberal statism"3 becomes the new status quo, inducing a scandalous increase of economic inequalities, forcing large populations to live precarious lives; in times where privatization of educational services in the context of market-oriented practices impose restrictive and ultimately unjust politics of accountability and performativity;4 in times where instrumentalization of educational ends has taken the lead, assisted by a systematic co-option and misappropriation of notions such as excellence and creativity;5 in times, finally, where spaces that allow for "the sharing (out) of the incalculable,"6 forging unknown potentialities in education, life, and thought, are being destroyed. In such times, Paul Woodford has stepped in, reclaiming his right to speak uncompromisingly.Hannah Arendt has written that "[w]hen men [sic] are deprived of the public space--which is constituted by acting together and then fills of its own accord [End Page 108] with the events and stories that develop into history--they retreat into their freedom of thought."7 Woodford refuses to retreat. He writes as a public intellectual of the highest order, committed to upset and not please those in power. A great service that his latest book performs is that it speaks daringly, stirring a debate that helps us all to do away with fear. For as Bertrand Russell has aptly said quite a long time ago, "[I]f thought is to become the possession of many, not the privilege of the few, we must have done with fear. It is fear that holds men [sic] back."8Resisting the "melancholy of inner exile,"9 but not immune to possible accusations of left melancholy, understood as "a refusal to come to terms with the particular character of the present,"10 the author wrote a book that provokes music educators to actively think beyond their sealed and safe world of convictions that is based on ideology-free conceptions of music teaching. Estelle Jorgensen has long ago brought to our attention the urgency of this task: "in an era in which the mindset and political reality have changed dramatically, … there is an urgent need to revisit the political character of music education and the ways in which it needs to address the cultural issues of our day."11Along this pathway, Woodford's book encourages music educators to live and teach as public intellectuals, forging "a democratic purpose for music education"12 that acts against the "anachronistic and formalist conception of music that reduces music education to supply-side economics as children are conceived as either future professional musicians or consumers and not as citizens to be prepared in schools to participate intelligently in the political life of society."13 Woodford articulates a vision of music education "as preparation for adulthood and democratic and global citizenship."14 He strongly advocates an approach that balances performance and creativity-based experiences with a socio-historical study of the social, ideological, and cultural workings of different musics in a wide variety of contexts. He encourages music educators to teach "how music's structural properties and qualities contribute to the shaping of people's perceptions and understandings of themselves and their world,"15 "asking the who, what, when, where, how, to, with, or for whom, and, most importantly of all, why of music."16 He envisions a music classroom that exercises social criticism "directly and self-consciously"17 both through "learning how to make music"18 and through thinking about music. He sees this approach as a tool for raising students' consciousness. Woodford's ultimate vision of music education is one that casts it as a means for cultivating "a justice-oriented" approach... (shrink)

In past and modern psychophysics there are several unresolved methodological and philosophical problems of human and animal perception, including the outstanding question of the relational basis of whole psychophysics. Here the main issue is discussed: if, and to what extent, there are viable bridges between the traditional “gestalt” oriented approaches and the modern perceptual-cognitive perspectives in psychophysics. Thereby the key concept of psychological “frame of reference” is presented by pointing to Hermann Ebbinghaus' geometric-optical illusions, on the one hand, and Max (...) Wertheimer's treatment of the traditional transposition phenomenon, on the other hand. A much-needed theoretical reorientation of future research may help to overcome the philosophical narrowness of present-day human and comparative psychophysics. (shrink)

La fondation de Nicopolis est la réponse donnée par Rome aux problèmes de l'organisation politique, administrative et sociale de l'Épire méridionale et de l'Acarnanie. Aussi les constructions telles que l'aqueduc constituent-elles, par leur inscription dans le paysage urbain et rural, un symbole majeur de la romanisation. Or le tracé de cet aqueduc, long de près de soixante-dix kilomètres, est encore imparfaitement connu. Nous en avons donc repris l'étude en nous attachant à reconstituer les contraintes auxquelles sa construction avait été soumise, (...) ainsi que l'évolution géomorphologique récente des bassins-versants traversés. Au-delà de l'aspect technique et naturaliste, nous nous sommes également attachés à replacer l'aqueduc dans le contexte territorial et géopolitique de l'époque. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Byzantine Matters by Averil CameronPanagiotis RoilosAveril Cameron. Byzantine Matters. Princeton, N.J.: Princeton University Press, 2014. xviii + 164 pp. 3 black-and-white maps. Cloth, $22.95.From C. P. Cavafy to W. B. Yeats, Ezra Pound, and more recently, Julia Kristeva, literary authors and intellectuals have eloquently (and as a rule more effectually than academics) shown that Byzantine matters are of noteworthy relevance to broader, i.e., not only scholarly, domains of (...) (post)modern culture too. Despite (or, at times, even because of) certain rather ineluctable limitations mainly deriving from its marked genre (general survey of the state of the field), Byzantine Matters belongs to that rare group of scholarly books that contribute considerably to the promotion of the Byzantine “cause” beyond the confines of the specific research and academic area. Written by one of the most eminent and influential scholars of late antiquity and early Byzantium, this book fulfills its valuable self-imposed aims: in a commendable, as a whole, interdisciplinary manner, it outlines the research trajectories that Byzantinists should pursue today, if they wish to expand their field’s methodological self-awareness and achieve a competitive level of theoretical sophistication.An important constituent of Averil Cameron’s critique of widespread preconceptions about Byzantium even in contemporary scholarly discourses (either in [End Page 719] the specialized research field or, more explicitly, in relevant ones) is her exposure of the detrimental ideological parameters of the exoticism and exceptionalism that often inform approaches to that past culture. The author’s task is not easy; on the contrary, it is bound to cause some distress or uneasiness in conservative scholarly circles (or “schools”).Cameron begins her discussion of the present state of Byzantine studies and of the related research desiderata by diagnosing the “absence” of Byzantium from hegemonic historiographic discourses in the so-called Western world. Origins and causes of this “absence” are astutely (albeit partially) traced back to influential Anglo-centric interpretive paradigms, these being of entirely derogatory (see Edward Gibbon’s notorious “history” and more recently the dogmatic conservatism of Arnold Toynbee and Samuel Huntington) or exoticizing, Orientalizing orientation (as exemplified in the activities of, e.g., Robert Byron and David Talbot Rice). Byzantium is shown to have been reduced to the state of the historical and historiographical “subaltern” of the West (9). Although I would have preferred to describe this idiosyncratic position of Byzantium in the dominant historiographic practice and the imaginary of the West in terms of what elsewhere I have defined as “para-marginality,” I must stress that Cameron’s sensitive outline of the Byzantine “absence” from established scholarly paradigms attests to her openness to sophisticated methodological schemata that might contribute to a creative and, whenever necessary, critical dialogue of Byzantine studies with related disciplines and broader theoretical debates.In her reappraisal of current scholarly views concerning the status of Byzantium as an empire, the author rightly emphasizes the adaptability and flexibility of Byzantine sociopolitical and economic structures and mechanisms, thus exposing the widespread view of an “unchanging Byzantium” as a mere “popular myth” (35). Equally noteworthy is her focusing on the contribution of ritual occasions and performances of ideologically and politically manipulated rhetoric to the reaffirmation, communication, and effectiveness of imperial power in Byzantium.Cameron’s learned approach to Byzantine art, which is introduced with a general discussion of the attraction it held for British authors (where, however, Ruskin’s work is conspicuously missing), and to the current state of its research places a judicious emphasis on the tension between iconoclasm and iconolatry as well as on issues of periodization. Of special significance is Cameron’s reference to the performative functions of icons in Byzantium and her call for new, interdisciplinary approaches to Byzantine art. However, the opposition between the written word and the image that the author, endorsing Michael Squire’s approach (74), puts forward is an unconvincing rhetorical construct rather than an always valid hermeneutic tool. Theology and religious practice in Byzantium never really reduced the written word to a state inferior to that of the image, as is evinced not only by the frequent coexistence of text and pictorial representation in Byzantine art but also by the extremely... (shrink)

Vain emotions are, according to Epicurus, the source of our mental disturbance. The aim of this paper is to discuss and analyze this connection by clarifying the structure of vain emotions in Epicurean philosophy. In order to achieve this, I present, first, the major lines of interpretation regarding the structure of epicurean emotions. Second, I highlight potential problems for each one of these interpretations. Third, I conclude that the existing interpretations cannot capture the whole picture regarding the epicurean structure of (...) emotions and thus I propose an alternative reading of the latter which surpasses the problems facing the existing interpretations. (shrink)

Nostalgia for the 1980s, or 80stalgia, is a global phenomenon. This article explores the phenomenon in Greece and approaches 80stalgia as a cultural trend that marks media and pop culture. It combines digital ethnography through invisible observation (especially using Facebook, a social medium that favours nostalgic communities) and historicised content analysis to analyse 80stalgia in its interrelation with politics, and approaches it as having been influenced by international nostalgic trends and local politics, especially the political legacy of 1980s governments. Finally, (...) the article discusses why the economic crisis of the 2010s, an experience that triggered self-reflection on the past, strengthened 80stalgia. (shrink)

Clinicians in their everyday practice of psychiatry face permanently the following epistemological and methodological problem: currently available psychiatric knowledge, like all types of scientific and technological knowledge, is general—at least in certain respects—in sharp contrast with the obvious particularities and even idiosyncrasies of each real individual mental patient they meet in the clinical encounter. This problem is admittedly the source of a permanent tension in the practice and above all in the philosophy of psychiatry. In the practice of psychiatry, conscientious (...) clinicians always try to find a necessarily pragmatic solution to this problem, mainly with the means of their psychiatric knowledge .. (shrink)

Against the traditional interpretation of Doxa as intrinsically and thoroughly deceiving and untrustworthy, the present essay examines the passages which follow the self-characterization of the goddess’ speech as ‘deceitful.’ The traits of an extensive cosmogony and cosmology open up the possibility for discerning two aspects of Doxa: first a presentation of mortal erroneous opinions, but then also their correction within the framework of the ‘appropriate world-arrangement’ presented by the goddess.

In this thesis I discuss the epistemological problems Socrates' faces as he inquires in the early Platonic dialogues into the nature of virtue , the way these problems are brought to a head in the Meno, and the way in which Plato resolves them in the Phaedo. ;I argue that Socrates conducts his investigation on the assumption that a human being will be virtuous, and happy, if and only if he is successful in instilling in his soul the arrangement that (...) is objectively proper for it. To do that he must improve his epistemic standing in quite a specific way: he must come to know in a substantive and practically efficacious way what is good and bad in general. Possession of this knowledge, in addition to being what it is to instill virtue in one's soul, is also the necessary and sufficient condition for one's happiness. ;I then argue that recent claims that Socrates distinguishes between different epistemic standards and that he disavows knowledge in a strict, but not in a weaker, sense are versions of the Insincerity Thesis . The Insincerity Thesis lacks philosophical motivation, and textual support. ;In the light of this, Meno's challenge in the Meno becomes a real, not a sophistical, problem, given the Socratic connections between being virtuous, knowing what virtue is in a substantive way, and being able to give in account of what one knows. The final solution is delivered in the Phaedo: There is an ontological affinity between us qua souls and the constitutive elements of the world, the ethical world included, on the basis of which we are epistemically able to carve the world at its natural joints. (shrink)

In this article, we take a closer look at the possible effects of adopting the IAS/fifrs standards around the globe. In order to determine what the IASB opinion regarding this impact is, we turned to the concerns of trustees. Using 3 interviews conducted with three of the trustees of IFRS on the possibility of creating a global accounting language, we realized a content analysis of the responses given. The results obtained after auto coding the responses of the trustees in NVivo, (...) a program used in qualitative analysis, highlighted that standards adoption is an important part of the accounting process in multiple countries, national experiences being significant to the board of trustees in order to make improvements to standards at a global level. (shrink)

Name der Zeitschrift: Rhizomata Jahrgang: 5 Heft: 2 Seiten: 113-147.

Until recently, cardiotoxicity in the setting of a malignant disease was attributed solely to the detrimental effects of chemo‐ and/or radio‐therapy to the heart. On this account, the focus was on the evaluation of well‐established cardiac biomarkers for the early detection of myocardial damage. Currently, this view has been revised. Cardiotoxicity is not restricted to a single organ but instead affects the endothelium as a whole. Indeed, it has come into light that not only cancer therapy but also malignant cells (...) per se can impair the cardiovascular system, through a paracrine and endocrine mode of action. Even more intriguingly, a clear interplay between molecular pathways involved in cancer and cardiovascular disease has become prevalent, suggesting a common nominator that governs the pathophysiology of these two entities. Taken together, our strategy in the quest of novel biomarkers in the emerging field of cardio‐oncology should be critically reshaped. (shrink)

Different why-questions emerge under different contexts and require different information in order to be addressed. Hence a relevance relation can hardly be invariant across contexts. However, what is indeed common under any possible context is that all explananda require scientific information in order to be explained. So no scientific information is in principle explanatorily irrelevant, it only becomes so under certain contexts. In view of this, scientific thought experiments can offer explanations, should we analyze their representational strategies. Their representations involve (...) empirical as well as hypothetical statements. I call this the “representational mingling” which bears scientific information that can explain events. Buchanan’s thought experiment from constitutional economics is examined to show how mingled representations explain. (shrink)

Do psychological perspectives constitute the only way through which the role of musical creativity in education can be addressed, researched and theorised? This essay attempts to offer an alternative view of musical creativity as a deeply social and political form of human praxis, by proposing a perspective rooted in the thought of the political philosopher and activist Cornelius Castoriadis (1922–1997). This is done in two steps. First, an attempt is made to place the pursuit of the concept of musical creativity (...) within a larger educational and societal context of conflicting trajectories that run through (a) Modernity and (b) Education. Then, I revisit the issue of educational value of improvising and composing through creating conceptual links between the process of music-making through improvisation and composition and the project of political autonomy as conceived by Castoriadis. By foregrounding instituting imaginary over instituted imaginary, improvising and composing become active processes of positing new legitimacies, and of creating a music-making context that searches for its own foundations. It is in and through creative musical praxis that we can think about issues of hierarchies, musical values, social dimensions of different music-making processes, our relationship to past values and to historical dimensions of music. By arguing that improvisation and composition might be seen as ways of positing the issue of political autonomy in musical terms, this paper emphasises the role of improvisation and composition as a mode of potentially transformative educational practice that may foster the development of critical consciousness, linking music education to a larger project of re-discovering and at the same time re-defining democracy. (shrink)

In A Philosophy for Communism: Rethinking Althusser Panagiotis Sotiris attempts a reading of the work of the French philosopher centered upon his deeply political conception of philosophy. Althusser's endeavour is presented as a quest for a new practice of philosophy that would enable a new practice of politics for communism, in opposition to idealism and teleology. The central point is that in his trajectory from the crucial interventions of the 1960s to the texts on aleatory materialism, Althusser remained a (...) communist in philosophy. This is based upon a reading of the tensions and dynamics running through Althusser's work and his dialogue with other thinkers. Particular attention is paid to crucial texts by Althusser that remained unpublished until relatively recently. (shrink)

The model of ownership psychology as a cognitive adaptation proposes that people flexibly navigate cognitive systems of cooperation and competition, thus enabling them to justify unethical behavior. We discuss how this model captures previous accounts of unethical behavior and propose that a disengagement heuristic can help us understand recent findings in the interconnection between scarcity psychology and unethical behavior.

This article deals with theories and political projects that can be defined as ‘left populism’. It begins with a reading and critique of the work of Ernesto Laclau on the theory of populism and then moves to recent debates about the possibility of left-populist movements. In contrast to these positions it attempts to present an alternative theoretical framework based on Gramscian notions, in order to rethink the notion of the people in ways that do not de-link it from class analysis (...) and social relations of production. (shrink)

Events regarding individuals’ preferences that do not always follow from standard measures such as “value of statistical life” or “quality-adjusted life years” as well as events that occur in some market-related settings which distort the information conveyed by price mechanisms, suggest that a notable chunk of what Hayek called “local knowledge” remains inaccessible by scientific tools and that only the individuals who interact in these local frameworks can have access to it. This casts serious doubt on the epistemic possibility of (...) economic calculation for if events in the local world do not observe the economic models, it is hard to see how central planners can have knowledge on them. Refined modeling strategies and cutting-edge Artificial Intelligence systems do not manage to overcome this hurdle. They may provide huge datasets in a data model, but since not all events represented in the data model are embeddable in known economic models, the knowledge problem is not evaded. Even if a theory ever manages to capture all possible events as they appear in the data model then we are left with a relationship between models (the theoretical model and the data model) with no direct access to the local world and thus the problem of accessibility of local knowledge remains unresolved. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 108 Heft: 1 Seiten: 1-52.

Exploring both the intrapersonal (moral) and interpersonal (ethical) nature of death and dying in the context of their development (philosophical), Dying in a Transhumanist and Posthuman Society shows how death and dying have been and will continue to be governed in any given society. Drawing on transhumanism and discourses about posthumanity, life prolongation and digital life, the book analyses death, dying and grief via the governance of dying. It states that the bio-medical dimensions of our understanding of death and dying (...) have predominated not only the discourses about death in society and the care of the dying, but their policy and practice as well. It seeks to provoke thinking beyond the benefits of technology and within the confinements of the world transhumanists describe. This book is written for all who have an interest in thanatology (i.e. death studies) but will be useful specifically to those investigating the experiences of dying and grieving in contemporary societies, wherein technology, biology and medicine continuously advance. Thus, the manuscript will be of interest to researchers in a broad range of areas including health and social care, social policy, anthropology, sociology, philosophy, cultural studies, and, of course, thanatology. (shrink)

First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

Peter Thomas has written an important book that brings forward the full importance of Gramsci’s strategic concepts and the pertinence they have for current theoretical and political debates. Based upon this interpretation of Gramsci, this text attempts a critical reading of the contradictory stance of the Althusserian School towards his work. Using Althusser’s own ambivalence towards Gramsci as a starting-point, the main aim of this article is to reconstruct Poulantzas’s direct and indirect dialogue with Gramsci. Despite Poulantzas’s reservations and criticisms (...) regarding aspects of Gramsci’s work, his theoretical endeavour not only is indebted to Gramsci, but also represents, despite its shortcomings and limits, one of the more original and profound theoretical attempts to come to terms with the theoretical challenges posed by Gramsci’s elaboration on hegemony, hegemonic apparatuses and the ‘integral state’. (shrink)

On the occasion of the publication of the translation of Pierre Raymond’s text on Althusser’s materialism, we attempt an introduction to his theoretical trajectory. We begin with his conception of the conflict between materialism and idealism inLe passage au matérialismein 1973 and his thinking on the question of the history of sciences inL’histoire & les sciences, before turning our attention to his elaboration on the question of a history of mathematics and in particular of the emergence of probabilistic reasoning. Then (...) we examine his confrontation with the question of the relation between materialism and dialectics inMatérialisme dialectique et logique. After that, we proceed to his conception of the need to break with any form of teleology and finalism as the starting point for a new conception of causality, before looking atDissiper la terreur et les ténèbresof 1992 and his attempt to rethink the question of practical reason. It is in light of the above presentation that we insist on the importance of Raymond’s text on Althusser. (shrink)

Panagiotis Kanellopoulos explores children's talk about musical thinking through the study of their reflections on their own improvised music. He accepts the possibility that children's discourse on music is the beginning of their philosophizing about music, an idea that is related to the larger issue of how to develop a music education perspective that gives voice to the learners and welcomes experimentation, constantly questioning the assumptions we bring as music educators. Based on particular examples of discussions with eight-year old (...) children he explores the development of their discourse, interpreting the meaning of their thinking, and illustrating how they put forward issues that although they begin from concrete particulars point to issues usually confined to abstract philosophical concerns. Children's reflective potential as well as their particular views has important educational implications. Discussions with the children about their work highlight interpretation and meaning-formation at the center of their experience as artists. And musical improvisation emerges as a source of genuine musical experiences and a core means for the creation of communities of practice, dialogue, and reflection. (shrink)

Socrates’ autobiography in Phaedo signifies an attempt to incorporate earlier philosophical thinking in a progressive evolution culminating in the Platonic theory of Forms. In the “second sailing”, the “hypothesis of Forms” is not a hypothetical assumption, an arbitrary claim or conjecture, but something to be “sup-posed” prior to any further knowledge or statement. The careful reading and reconstruction of the famous simile of the “sun in eclipse” leads to crucial consequences concerning the attempt to “take refuge in the logoi”. The (...) Forms “sup-posed” in the logoi do not indicate a new “transcendent” object, but aim at the same target as that of the senses: at the truth of beings of our world. The “second sailing” follows a different route, but has the same direction as the “first sailing” of the physiologoi. (shrink)

White liberals like to claim that they live in a post-racial society. Furthermore, they believe that most people do not sympathize with the far-right. However, it is not racism fueling right-wing extremism in North America and Western Europe but the dominant ideology, liberalism. Consequently, Slavoj Žižek argues that racism is a problem concerning “objective violence,” which he further breaks down into “symbolic violence” and “systemic violence.” These primarily target minority groups. Thus, “objective violence” best explains the West’s problematic views of (...) Muslims and Islam since it supports what Edward Said refers to as “Orientalism” and reproduces racist depictions of racialized communities. These are incredibly harmful since the West still perceives the Orient and its residents as violent, strange, and backward. These Orientalist attitudes ultimately lead to discrimination against Muslims and Arabs. Furthermore, this ideology naturalizes and legitimizes capitalist social relations while concealing racialization processes. (shrink)

COVID-19 is not only a health emergency but also a strategic challenge for any politics of resistance, struggle and transformation. Understanding the social and political dynamics associated with morbidity and mortality and the many ‘ecologies of disease’ associated with the pandemic is necessary if we want to think beyond the limits of the lockdown strategy. It is here that the possibility of a democratic biopolitics emerges as part of a broader strategy for communism.